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The University of Dayton has produced several distinguished graduates who have made significant contributions in their respective fields. Some notable alumni include:

• David J. Bradley: He is renowned as the creative mind behind the invention of the computer keyboard command "Control-Alt-Delete."

• Bill Klesse: He has achieved great success as the CEO of Valero Energy, a prominent company in the energy sector.

• Charles J. Pedersen: This accomplished individual was honoured with the Nobel Prize in Chemistry in 1987 for his exceptional contributions to the field.

• Candace Smith: She is a versatile talent known for her accomplishments as an actress, and model, and for being crowned Miss Ohio USA in 2003. Additionally, she participated in the reality TV show "Survivor."

• Jon A. Husted: A graduate of the University of Dayton, he has served as the Ohio Lieutenant Governor from 2019 to the present.